ANAPC4 antibody (N-Term)

Catalog No. ABIN1887874

Product Details anti-ANAPC4 Antibody

Target: ANAPC4 (Anaphase Promoting Complex Subunit 4 (ANAPC4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANAPC4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the amino terminus of human APC4.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for ANAPC4

Target: ANAPC4 (Anaphase Promoting Complex Subunit 4 (ANAPC4))

Alternative Name: APC4 (ANAPC4 Products)

Synonyms: MGC81278 antibody, DDBDRAFT_0186409 antibody, DDBDRAFT_0234268 antibody, DDB_0186409 antibody, DDB_0234268 antibody, APC4 antibody, ANAPC4 antibody, 2610306D21Rik antibody, D5Ertd249e antibody, F18E5.150 antibody, F18E5_150 antibody, anaphase promoting complex subunit 4 antibody, anaphase promoting complex subunit 4 L homeolog antibody, Transducin/WD40 repeat-like superfamily protein antibody, Anapc4 antibody, anapc4.L antibody, ANAPC4 antibody, anapc4 antibody, APC4 antibody

Background: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis.APC4 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence.The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.While little is known of APC4, it is thought that APC4 associates with other APC/C components APC1, APC5, and CDC23 interdependently, such that loss of any one subunit reduces binding between the remaining three.
Synonyms: Anaphase promoting complex 4, ANAPC4

UniProt: Q9UJX5

Pathways: M Phase