PAPPA2 antibody (N-Term)

Catalog No. ABIN1887939

Product Details anti-PAPPA2 Antibody

Target: PAPPA2 (Pappalysin 2 (PAPPA2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAPPA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the amino terminus of human PLAC3.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for PAPPA2

Target: PAPPA2 (Pappalysin 2 (PAPPA2))

Alternative Name: PLAC3 (PAPPA2 Products)

Synonyms: PAPP-A2 antibody, PLAC3 antibody, Pappe antibody, PAPP-E antibody, PAPPE antibody, si:dkey-39f8.1 antibody, pappalysin 2 antibody, Pappa2 antibody, PAPPA2 antibody, pappa2 antibody

Background: PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion.It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth.Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
Synonyms: Placenta-specific protein 3, Pappalysin 2, pregnancy-associated plasma protein A2, PAPP-A2, PAPPA2

NCBI Accession: NP_064714