SATB2 antibody (N-Term)

Catalog No. ABIN1888018

Product Details anti-SATB2 Antibody

Target: SATB2 (SATB Homeobox 2 (SATB2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SATB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity (Details): At least two isoforms of SATB2 are known to exist. This SATB2 antibody will not cross-react with SATB1.

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the amino terminus of the human SATB2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SATB2

Target: SATB2 (SATB Homeobox 2 (SATB2))

Alternative Name: SATB2 (SATB2 Products)

Synonyms: RGD1562369 antibody, mKIAA1034 antibody, SATB homeobox 2 antibody, special AT-rich sequence binding protein 2 antibody, SATB2 antibody, satb2 antibody, Satb2 antibody

Background: Human special AT-rich sequence-binding protein-2 (SATB2) is a nuclear matrix/scaffold-associated region DNA-binding protein.Like its homolog SATB1, SATB2 selectively binds double-stranded, special AT-rich DNA sequences, but is expressed primarily in a subset of postmitotic, differentiating neurons in the neocortex.Mice deficient in SATB exhibit craniofacial abnormalities and defects in osteoblast differentiation and function.SATB2 also interacts with and enhances the activity of Runx2 and ATF4, two transcription factors that regulate osteoblast differentiation, indicating that SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.Recent experiments have shown that SATB2 interacts with histone deacetylase 1 and metastasis-associated protein 2, two proteins that are involved in chromatin remodeling, suggesting that SATB2 may also be involved in mediating epigenetic influences during cortical development.
Synonyms: DNA-binding protein SATB2, Special AT-rich sequence-binding protein 2

UniProt: Q9UPW6