DARC antibody (N-Term)

Catalog No. ABIN1888072

Product Details anti-DARC Antibody

Target: DARC (Duffy Blood Group, Chemokine Receptor (DARC))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DARC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide from near the amino terminus of human DARC.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for DARC

Target: DARC (Duffy Blood Group, Chemokine Receptor (DARC))

Alternative Name: DARC (DARC Products)

Synonyms: DARC antibody, FY antibody, ACKR1 antibody, CCBP1 antibody, CD234 antibody, Dfy antibody, GPD antibody, GpFy antibody, WBCQ1 antibody, AA162249 antibody, Ackr1 antibody, ESTM35 antibody, Duffy blood group, chemokine receptor antibody, atypical chemokine receptor 1 (Duffy blood group) antibody, atypical chemokine receptor 1 antibody, DARC antibody, ACKR1 antibody, Ackr1 antibody

Background: DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling.DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines.Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein.It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases.At least three isoforms of DARC are known to exist.
Synonyms: Duffy antigen, Fy glycoprotein, GpFy, Cell adhesion molecule 3, CADM3

UniProt: Q16570