CDC16 antibody (N-Term)

Catalog No. ABIN1888148

Product Details anti-CDC16 Antibody

Target: CDC16 (Cell Division Cycle 16 Homolog (S. Cerevisiae) (CDC16))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC16 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: APC6 antibody was raised against an 18 amino acid peptide near the amino terminus of human APC6.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for CDC16

Target: CDC16 (Cell Division Cycle 16 Homolog (S. Cerevisiae) (CDC16))

Alternative Name: APC6 (CDC16 Products)

Synonyms: zgc:123264 antibody, F9K20.19 antibody, F9K20_19 antibody, anaphase promoting complex 6 antibody, 2700071J12Rik antibody, 2810431D22Rik antibody, APC6 antibody, ANAPC6 antibody, CUT9 antibody, cell division cycle 16 antibody, cell division cycle 16 L homeolog antibody, cell division cycle 16 homolog (S. cerevisiae) antibody, cell division cycle protein 16 homolog antibody, anaphase promoting complex 6 antibody, CDC16 cell division cycle 16 antibody, CDC16 antibody, cdc16.L antibody, cdc16 antibody, LOC100434328 antibody, APC6 antibody, Cdc16 antibody

Background: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis.APC6 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence.The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.While little is known of APC6, it has been shown to interact with and is stabilized by CDC26 through an intermolecular TPR mimic composed of one helix from each protein.
Synonyms: Anaphase promoting complex 6, ANAPC6, CDC16

NCBI Accession: NP_003894

Pathways: Regulation of Actin Filament Polymerization