TM4SF1 antibody (N-Term)

Catalog No. ABIN1888233

Product Details anti-TM4SF1 Antibody

Target: TM4SF1 (Transmembrane 4 L Six Family Member 1 (TM4SF1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TM4SF1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity (Details): At least three isoforms of TM4SF1 are known to exist, this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.

Purification: Affinity chromatography purified via peptide column

Immunogen: TM4SF1 antibody was raised against an 18 amino acid peptide near the amino terminus of human TM4SF1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for TM4SF1

Target: TM4SF1 (Transmembrane 4 L Six Family Member 1 (TM4SF1))

Alternative Name: TM4SF1 (TM4SF1 Products)

Synonyms: MGC85546 antibody, h-l6 antibody, m3s1 antibody, taal6 antibody, H-L6 antibody, L6 antibody, M3S1 antibody, TAAL6 antibody, MM3 antibody, M3s1 antibody, transmembrane 4 L six family member 1 antibody, transmembrane 4 L six family member 1 S homeolog antibody, transmembrane 4 superfamily member 1 antibody, TM4SF1 antibody, tm4sf1.S antibody, tm4sf1 antibody, Tm4sf1 antibody

Background: TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers.Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.
Synonyms: Transmembrane 4 L6 family member 1, L6, H-L6, M3S1, TAAL6

NCBI Accession: NP_055035