TNFRSF12A antibody

Catalog No. ABIN1888241

Product Details anti-TNFRSF12A Antibody

Target: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF12A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: human IgG1 Fc-tagged Fn14 protein.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for TNFRSF12A

Target: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Alternative Name: Fn14 (TNFRSF12A Products)

Synonyms: CD266 antibody, FN14 antibody, TWEAKR antibody, AI255180 antibody, C87282 antibody, Fn14 antibody, HPIP antibody, TWEAK-R antibody, TweakR antibody, TNF receptor superfamily member 12A antibody, tumor necrosis factor receptor superfamily, member 12a antibody, TNFRSF12A antibody, Tnfrsf12a antibody

Background: TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis.These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily.Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules.Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas.In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.
Synonyms: Fibroblast growth factor-inducible 14, TNFRSF12, TWEAK-R

NCBI Accession: NP_057723

Pathways: Apoptosis, Regulation of Cell Size