CACNA2D1 antibody (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1) (Internal Region)

Details for Product anti-CACNA2D1 Antibody No. ABIN190770, Supplier: Log in to see
Antigen
  • CACNA2D1
  • DKFZp469K2211
  • CACNA2
  • CACNL2A
  • CCHL2A
  • Ca(v)alpha2delta1
  • Cacna2
  • Cchl2a
  • CCHLA2
  • DHSCCA
  • calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • calcium channel, voltage-dependent, alpha2/delta subunit 1
  • CACNA2D1
  • cacna2d1
  • Cacna2d1
Epitope
Internal Region
25
10
4
4
2
2
1
1
1
1
1
Reactivity
Human
71
19
18
4
4
3
2
2
2
Host
Goat
58
15
1
Clonality
Polyclonal
Conjugate
This CACNA2D1 antibody is un-conjugated
5
5
5
3
3
3
Method Type
Peptide ELISA
Application
ELISA, Western Blotting (WB)
59
37
14
11
5
2
2
1
1
1
Options
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Immunogen Peptide with sequence C-QEIFNKYNKDKKVR, from the internal region of the protein sequence according to NP_000713.2.
Blocking Peptide Blocking peptide for this product available: ABIN369615
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Grade Verified
Alternative Name CACNA2D1 (CACNA2D1 Antibody Abstract)
Background Synonyms: CACNA2D1, calcium channel, voltage-dependent, alpha 2/delta subunit 1, CACNA2, CACNL2A, CCHL2A, MHS3, H_DJ0560O14.1, WUGSC:H_DJ0560O14.1, calcium channel, L type, alpha 2 polypeptide, dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit
Gene ID 781, 12293, 25399
NCBI Accession NP_000713
Application Notes ELISA: antibody detection limit dilution 1:16000.
Western blot: Approx 140 kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 123 kDa according to NP_000713.2). Recommended concentration: 0.03-0.1 µg/mL. Customer found it not suitable on Mouse and Rat protein.
Restrictions For Research Use only
Format Liquid
Concentration 100µg/200µl
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
 image for anti-CACNA2D1 antibody (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1) (Internal Region) (ABIN190770) ABIN190770 (0.03µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in R...
Product cited in: Neely, Hess, Costigan, Keene, Goulas, Langeslag, Griffin, Belfer, Dai, Smith, Diatchenko, Gupta, Xia, Amann, Kreitz, Heindl-Erdmann, Wolz, Ly, Arora, Sarangi, Dan, Novatchkova, Rosenzweig, Gibson et al.: "A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. ..." in: Cell, Vol. 143, Issue 4, pp. 628-38, 2010 (PubMed).

Background publications Hullin, Matthes, von Vietinghoff, Bodi, Rubio, DSouza, Friedrich Khan, Rottländer, Hoppe, Mohacsi, Schmitteckert, Gilsbach, Bünemann, Hein, Schwartz, Herzig: "Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure." in: PLoS ONE, Vol. 2, Issue 3, pp. e292, 2007 (PubMed).