Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pThr645) antibody

Details for Product No. ABIN196703
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Antigen
Synonyms D12S1644, IL-4-STAT, STAT6B, STAT6C
Epitope
pThr645
(48), (33), (21), (12), (7), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(246), (99), (90), (15), (12), (8), (4)
Host
Rabbit
(207), (51), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(195), (85), (78), (54), (41), (30), (22), (18), (15), (6), (5), (1)
Pubmed 4 references available
Quantity 50 μg
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Catalog No. ABIN196703
286.00 $
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human STAT6 around the phosphorylation site of threonine 645 (P-A-TP-I-K).
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. STAT6 (phospho-Thr645) antibody detects endogenous levels of STAT6 only when phosphorylated at threonine 645.
Purification Immunoaffinity chromatography.
Alternative Name STAT6
Background Alternate names: IL-4 Stat, Signal transducer and activator of transcription 6
Gene ID 6778
NCBI Accession NP_001171549
UniProt P42226
Research Area Chromatin and Nuclear Signaling, Signaling, Receptors, Inflammation
Application Notes Suitable for use in Immunohistochemistry (1: 50-1: 100). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Supplier Images
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pThr645) antibody anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pThr645) antibody
Background publications Quelle, Shimoda, Thierfelder et al.: "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis." in: Molecular and cellular biology, Vol. 15, Issue 6, pp. 3336-43, 1995 (PubMed).

Hou, Schindler, Henzel et al.: "An interleukin-4-induced transcription factor: IL-4 Stat." in: Science (New York, N.Y.), Vol. 265, Issue 5179, pp. 1701-6, 1994 (PubMed).

Malabarba, Rui, Deutsch et al.: "Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha." in: The Biochemical journal, Vol. 319 ( Pt 3), pp. 865-72, 1996 (PubMed).

Nelms, Keegan, Zamorano et al.: "The IL-4 receptor: signaling mechanisms and biologic functions." in: Annual review of immunology, Vol. 17, pp. 701-38, 1999 (PubMed).

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