Lipocalin 2 antibody (AA 1-198) (FITC)

Catalog No. ABIN1993327

Product Details anti-Lipocalin 2 Antibody (FITC)

Target: Lipocalin 2 (LCN2)

Binding Specificity: AA 1-198

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lipocalin 2 antibody is conjugated to FITC

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human NGAL protein (1-198AA)

Isotype: IgG

Application Details

Application Notes: Optimal working concentration should be determinde by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Lipocalin 2

Target: Lipocalin 2 (LCN2)

Alternative Name: LCN2 (LCN2 Products)

Synonyms: LCN2 antibody, 24p3 antibody, MSFI antibody, NGAL antibody, AW212229 antibody, Sip24 antibody, lipocalin 2 antibody, LCN2 antibody, Lcn2 antibody

Background:

Background: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Aliases: 24p3 antibody, 25 kDa alpha 2 microglobulin related subunit of MMP9 antibody, 25 kDa alpha-2-microglobulin-related subunit of MMP-9 antibody, Alpha 2 microglobulin related protein antibody, HGNC:6526 antibody, HNL antibody, Lcn 2 antibody, Lcn2 antibody, Lipocalin-2 antibody, Migration stimulating factor inhibitor antibody, MSFI antibody, Neutrophil gelatinase associated lipocalin antibody, Neutrophil gelatinase associated lipocalin precursor antibody, Neutrophil gelatinase-associated lipocalin antibody, NGAL antibody, NGAL_HUMAN antibody, Oncogene 24p3 antibody, Oncogenic lipocalin 24p3 antibody, p25 antibody, Siderocalin antibody, siderocalin LCN2 antibody, SV40 induced 24P3 protein antibody, Uterocalin antibody

UniProt: P80188

Pathways: Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis