PARK7/DJ1 antibody (AA 1-188)
-
- Target See all PARK7/DJ1 (PARK7) Antibodies
- PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
-
Binding Specificity
- AA 1-188
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This PARK7/DJ1 antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Protein DJ-1 protein (1-188AA)
- Isotype
- IgG
- Top Product
- Discover our top product PARK7 Primary Antibody
-
-
- Application Notes
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClinTM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
- Alternative Name
- PARK7 (PARK7 Products)
- Synonyms
- DJ-1 antibody, DJ1 antibody, CAP1 antibody, Dj1 antibody, SP22 antibody, dj1 antibody, zgc:103725 antibody, park7b antibody, park7 antibody, park7a antibody, Parkinsonism associated deglycase antibody, Parkinson disease (autosomal recessive, early onset) 7 antibody, parkinson protein 7 antibody, parkinson protein 7 S homeolog antibody, parkinson protein 7 L homeolog antibody, PARK7 antibody, Park7 antibody, park7 antibody, park7.S antibody, park7.L antibody
- Background
-
Background: PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies (Rizzu et al. 2004). Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson\'s disease 7 (PARK7). Parkinson\'s disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways.
Aliases: CAP1 antibody, DJ-1 antibody, DJ1 antibody, DJ1 protein antibody, Epididymis secretory sperm binding protein Li 67p antibody, FLJ27376 antibody, FLJ34360 antibody, FLJ92274 antibody, HEL S 67p antibody, Oncogene DJ1 antibody, OTTHUMP00000001348 antibody, OTTHUMP00000001349 antibody, OTTHUMP00000001350 antibody, OTTHUMP00000001351 antibody, PARK7 antibody, PARK7_HUMAN antibody, Parkinson disease (autosomal recessive, early onset) 7 antibody, Parkinson disease protein 7 antibody, Parkinson protein 7 antibody, Protein DJ-1 antibody, SP22 antibody
- UniProt
- Q99497
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
-