ARAP1 antibody (AA 1190-1450)

Catalog No. ABIN238383

The Mouse Monoclonal anti-ARAP1 antibody (Clone ARAP1-2) (ABIN238383) specifically detects ARAP1 in WB, IP and IF. The antibody is reactive with Human samples.

Quick Overview for ARAP1 antibody (AA 1190-1450) (ABIN238383)

Target: ARAP1 (ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ARAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: ARAP1-2

Product Details anti-ARAP1 Antibody

Binding Specificity: AA 1190-1450

Specificity: The antibody ARAP1-2 reacts with C-terminal part of ARAP1, a 160 kDa adaptor protein.

Characteristics: Synonyms: KIAA0782, Centaurin-delta-2, Arf-GAP, Rho-GAP domain, ANK repeat and PHdomain-containing protein 1

Purification: Protein A affinity chromatography

Immunogen: His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1

Isotype: IgG1

Application Details

Application Notes: Suitable for Western Blotting (2 μg/mL). Immunoprecipitation. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 with 15 mM sodium azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for ARAP1

Target: ARAP1 (ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1))

Alternative Name: ARAP1 / CENTD2

Background: ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.Synonyms: ANK repeat and PH domain-containing protein 1, Arf-GAP, Centaurin-delta-2, KIAA0782, Rho-GAP domain

Gene ID: 116985

UniProt: Q96P48