ARAP1 antibody (AA 1190-1450)

Catalog No. ABIN302078

There is 1 publication for this product available. The Mouse Monoclonal anti-ARAP1 antibody is suitable to detect ARAP1 in samples from Human. It has been validated for WB, IP and ICC.

Quick Overview for ARAP1 antibody (AA 1190-1450) (ABIN302078)

Target: ARAP1 (ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ARAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: ARAP1-2

Product Details anti-ARAP1 Antibody

Binding Specificity: AA 1190-1450

Purpose: Anti-ARAP1 Purified

Cross-Reactivity (Details): Human

Characteristics: The antibody ARAP1-2 reacts with C-terminal part of ARAP1 (intracellular epitope), a 160 kDa adaptor protein.

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1

Isotype: IgG1

Application Details

Application Notes: Western blotting: Recommended dilution: 2 μg/mL

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-ARAP1 antibody (ABIN302078)

Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).

Target Details for ARAP1

Target: ARAP1 (ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1))

Alternative Name: ARAP1

Background: ArfGAP with RhoGAP domain, ankyrin repeat and PH d,ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.,CED2, CENTD2

Gene ID: 116985

UniProt: Q96P48