Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibody (PE)

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B)

Synonyms: DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5, TNFRSF10B, dr5, cd262, killer, trick2, trickb, xDR-M1, xDR-M2, ztnfr9, trailr2, trick2a, trick2b, MGC88957

Clonality: Monoclonal (DR5-01-1)

Host: Mouse

Reactivity: Human

Conjugate: PE

Application: Flow Cytometry (FACS)

Catalog no.: ABIN238402

Additional Information

Characteristics: Synonyms: TNFRSF10B, DR5, KILLER, TRICK2, ZTNFR9, Death receptor 5, TRAIL receptor 2, TRAIL-R2,Tumor necrosis factor receptor superfamily member 10B, TNF-related apoptosis-inducingligand receptor 2

Alternative name: CD262 / TRAILR2

Swiss-Prot: O14763

Immunogen: Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.

Cross-Reactivity: Human

Isotype: IgG1

Clone: DR5-01-1

Description: TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domaincontaining receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation anddevelopment of multicellular organisms. Apoptosis is induced by certain cytokinesincluding tumor necrosis factor (TNF) and Fas ligand in the TNF family through their deathdomain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Anothermember in the TNF family has been identified and designated TRAIL (for TNF relatedapoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include twodeath domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like therelated death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signalingapoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal humantissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is amember of the TNF receptor superfamily, and contains an intracellular death domain. Thisreceptor can be activated by tumor necrosis factor related apoptosis inducing ligand(TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficientmice suggested that FADD, a death domain containing adaptor protein, is required for theapoptosis mediated by this protein.

Specificity: The antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 isone of two TNF superfamily member intracellular death domain containing receptors forTRAIL (APO2L). Species: HumanOthers not tested.

Application Details

Application Notes: Flow Cytometry analysis: 5 µg/ml.

Concentration: 0.1 mg/ml

Buffer: PBS containing 15 mM sodium azide as preservative and 0.2% (w/v)high-grade BSA (Protease free) as stabilizer.Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions.

Storage: Store the antibody in the dark at 2-8°C. DO NOT FREEZE! Avoid prolonged exposure to light. Shelf life: one year from despatch.

Research Area: Signaling, Apoptosis/Necrosis

Restrictions: For Research Use only