CD16 antibody

Catalog No. ABIN238452

Product Details anti-CD16 Antibody

Target: CD16

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD16 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: The antibody MEM-168 reacts with CD16 antigen (isoform CD16a). CD16a (FcγRIIIA, 50-65 kDa) is a transmembrane form of CD16, expressed on NK-cells, monocytes and macrophages.

Cross-Reactivity (Details): Species reactivity (tested):Human, Non-Human Primates, Porcine

Characteristics: Synonyms: IgG Fc receptor III-2, Fc-gamma RIII-alpha, FcR-10, CD16a, FCGR3A, FCG3, IGFR3, Fc-gammaRIIIa, FcRIIIa, Fc-gamma RIII, Low affinity immunoglobulin gamma Fc region receptor III-A

Purification: Gel filtration and Precipitation methods

Immunogen: Human granulocytes.

Clone: MEM-168

Isotype: IgM

Application Details

Application Notes: Suitable for Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS with 15 mM sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD16

Target: CD16

Alternative Name: CD16 (CD16 Products)

Synonyms: Fcgr3 antibody, Fcgr3a antibody, CD16 antibody, FCGR3 antibody, FCGR3@ antibody, CD16b antibody, FCG3 antibody, FCR-10 antibody, FCRIII antibody, FCRIIIb antibody, FcRIII antibody, Fc fragment of IgG, low affinity IIa, receptor antibody, Fc fragment of IgG, low affinity IIIa, receptor (CD16a) antibody, Fc fragment of IgG receptor IIIb antibody, Fc fragment of IgG receptor IIIa antibody, Fc receptor, IgG, low affinity III antibody, Fc-gamma RIII antibody, Fcgr2a antibody, FCGR3A antibody, FCGR3B antibody, Fcgr3 antibody, FCGR3 antibody

Background: CD16 (FcγRIII) is a 50-80 kDa glycoprotein serving as a low affinity IgG receptor. Human FcγRIII is expressed in two forms FcγRIII-A and -B. FcγRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcεRI-γ subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcγRIII-A is associated, moreover, with FcεRI-β subunit. Besides IgG, FcεRI-A can be triggered also by oligomeric IgE. FcγRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.Synonyms: CD16A, FCG3, FCGR3, FCGR3A, Fc-gamma RIII, Fc-gamma RIII-alpha, Fc-gamma RIIIa, FcR-10, FcRIII, FcRIIIa, IGFR3, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A

Gene ID: 2214

UniProt: P08637

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process