zgc:66383 antibody, CRELD2 antibody, 5730592L21Rik antibody, C85758 antibody, RGD1310614 antibody, cysteine-rich with EGF-like domains 2 antibody, cysteine rich with EGF like domains 2 antibody, creld2 antibody, CRELD2 antibody, Creld2 antibody
Background
CRELD2 (cysteine-rich with EGF-like domains 2) is a 353 amino acid protein that is ubiquitously expressed and contains two FU domains and two EGF-like domains. Localized to the endoplasmic reticulum and secreted into the cell, CRELD2 interacts with AChR4, possibly regulating its transport. Human CRELD2 shares 69 % amino acid identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of CRELD2 exist due to alternative splicing events. The gene encoding CRELD2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome.