PDE10A antibody
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- Target See all PDE10A Antibodies
- PDE10A (phosphodiesterase 10A (PDE10A))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This PDE10A antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Characteristics
- Homo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2
- Purification
- Purified from mouse ascites fluids by affinity chromatography
- Immunogen
- Full length human recombinant protein of human PDE10A (NP_006652) produced in HEK293T cell.
- Clone
- 4A10
- Isotype
- IgG1
- Top Product
- Discover our top product PDE10A Primary Antibody
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- Application Notes
- WB:1:500, FC:1:50
- Comment
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The concentration of the product may vary between diferrent lots.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5-1.0 mg/mL
- Buffer
- PBS ( pH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
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- Target
- PDE10A (phosphodiesterase 10A (PDE10A))
- Alternative Name
- PDE10A (PDE10A Products)
- Synonyms
- HSPDE10A antibody, Pde10a3 antibody, phosphodiesterase 10A antibody, PDE10A antibody, Pde10a antibody
- Background
- Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11, PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously,with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility,platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.
- Molecular Weight
- 88.4 kDa
- Gene ID
- 10846
- NCBI Accession
- NM_006661
- HGNC
- 10846
- Pathways
- cAMP Metabolic Process
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