DUSP12 antibody

Catalog No. ABIN2457984

Product Details anti-DUSP12 Antibody

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DUSP12.

Application Details

Application Notes: DUSP12 antibody can be used for detection of DUSP12 by ELISA at 1:1562500. DUSP12 antibody can be used for detection of DUSP12 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store DUSP12 antibody at -20 °C.

Target Details for DUSP12

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Alternative Name: DUSP12 (DUSP12 Products)

Synonyms: DUSP12 antibody, dusp12 antibody, zgc:114069 antibody, MGC154526 antibody, DUSP1 antibody, YVH1 antibody, 1190004O14Rik antibody, AA027408 antibody, AW049275 antibody, ESTM36 antibody, LMW-DSP4 antibody, T-DSP4 antibody, VH1 antibody, mVH1 antibody, GKAP antibody, dual specificity phosphatase 12 antibody, dual specificity phosphatase 12 L homeolog antibody, Dual specificity protein phosphatase 12 antibody, dual specificity protein phosphatase 12 antibody, DUSP12 antibody, dusp12 antibody, dusp12.L antibody, GL50803_36315 antibody, MGYG_01770 antibody, Dusp12 antibody

Background: DUSP12 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP12 is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Molecular Weight: 38 kDa

Gene ID: 11266

NCBI Accession: NP_009171

UniProt: Q9UNI6

Pathways: Regulation of Carbohydrate Metabolic Process