PPP4R2 antibody

Catalog No. ABIN2458684

Product Details anti-PPP4R2 Antibody

Target: PPP4R2 (Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP4R2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PPP4R2.

Application Details

Application Notes: PPP4R2 antibody can be used for detection of PPP4R2 by ELISA at 1:62500. PPP4R2 antibody can be used for detection of PPP4R2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PPP4R2 antibody at -20 °C.

Target Details for PPP4R2

Target: PPP4R2 (Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2))

Alternative Name: PPP4R2 (PPP4R2 Products)

Synonyms: PP4R2 antibody, BE691708 antibody, C230060M08Rik antibody, ppp4r2 antibody, fe11b04 antibody, wu:fe11b04 antibody, ppp4r2-B antibody, wu:fa17h08 antibody, wu:fc23g05 antibody, protein phosphatase 4 regulatory subunit 2 antibody, protein phosphatase 4, regulatory subunit 2 antibody, protein phosphatase 4, regulatory subunit 2a antibody, protein phosphatase 4 regulatory subunit 2 S homeolog antibody, protein phosphatase 4 regulatory subunit 2 L homeolog antibody, protein phosphatase 4, regulatory subunit 2b antibody, PPP4R2 antibody, Ppp4r2 antibody, ppp4r2a antibody, ppp4r2.S antibody, ppp4r2 antibody, ppp4r2.L antibody, ppp4r2b antibody

Background: PPP4R2 is the regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). It may regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

Molecular Weight: 47 kDa

Gene ID: 151987

NCBI Accession: NP_777567

UniProt: Q9NY27