PAICS antibody

Catalog No. ABIN2458982

Product Details anti-PAICS Antibody

Target: PAICS (phosphoribosylaminoimidazole Carboxylase, phosphoribosylaminoimidazole Succinocarboxamide Synthetase (PAICS))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAICS antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PAICS.

Application Details

Application Notes: PAICS antibody can be used for detection of PAICS by ELISA at 1:312500. PAICS antibody can be used for detection of PAICS by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PAICS antibody at -20 °C.

Target Details for PAICS

Target: PAICS (phosphoribosylaminoimidazole Carboxylase, phosphoribosylaminoimidazole Succinocarboxamide Synthetase (PAICS))

Alternative Name: PAICS (PAICS Products)

Synonyms: cb293 antibody, sb:cb293 antibody, wu:fa28a05 antibody, GB14262 antibody, DDBDRAFT_0218550 antibody, DDBDRAFT_0230088 antibody, DDB_0218550 antibody, DDB_0230088 antibody, AIRC antibody, AS antibody, ADE2 antibody, ADE2H1 antibody, PAIS antibody, Ade2h1 antibody, Airc antibody, ade2 antibody, airc antibody, paics antibody, pais antibody, 2610511I09Rik antibody, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase antibody, phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase antibody, multifunctional protein ADE2 antibody, phosphoribosylaminoimidazole carboxylase antibody, phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, gene 2 L homeolog antibody, phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase antibody, PAICS antibody, paics antibody, LOC551966 antibody, Tsp_02239a antibody, Tsp_02239 antibody, CNE02500 antibody, purC/E antibody, Paics antibody, paics.2.L antibody

Background: PAICS is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 47 kDa

Gene ID: 10606

NCBI Accession: NP_001072992

UniProt: P22234

Pathways: Chromatin Binding