PAICS Products
(phosphoribosylaminoimidazole Carboxylase, phosphoribosylaminoimidazole Succinocarboxamide Synthetase (PAICS))
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This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured PAICS Categories
PAICS Antibodies
High quality antibodies with extensive validation data.
PAICS Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PAICS Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (4)
Cat. No.
ABIN656869
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7160326
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7237569
Quantity
200 μL
Datasheet
Datasheet
Recommended PAICS ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6229169
Quantity
96 tests
Datasheet
Datasheet
Recommended PAICS Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124444
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313911
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3086731
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PAICS products
: "Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer." in: Oncotarget, Vol. 6, Issue 14, pp. 12587-602, (2015) (PubMed).: "Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders." in: Molecular genetics and metabolism, Vol. 108, Issue 3, pp. 178-89, (2013) (PubMed).
: "Transiently transfected purine biosynthetic enzymes form stress bodies." in: PLoS ONE, Vol. 8, Issue 2, pp. e56203, (2013) (PubMed).
Synonyms and alternative names related to PAICS
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (paics), multifunctional protein ADE2 (LOC551966), multifunctional protein ADE2 (Tsp_02239a), multifunctional protein ADE2 (Tsp_02239), phosphoribosylaminoimidazole carboxylase (CNE02500), phosphoribosylaminoimidazole carboxylase (purC/E), phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (Paics), phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, gene 2 L homeolog (paics.2.L), phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase (Paics), 2610511I09Rik, ADE2, ade2, ADE2H1, Ade2h1, AIRC, Airc, airc, AS, cb293, DDBDRAFT_0218550, DDBDRAFT_0230088, DDB_0218550, DDB_0230088, GB14262, paics, PAIS, pais, sb:cb293, wu:fa28a05Protein level used designations for PAICS
- multifunctional protein ADE2
- phosphoribosylaminoimidazole carboxylase
- phosphoribosylaminoimidazolesuccinocarboxamide synthase
- AIR carboxylase domain
- AIR carboxylase
- SAICAR synthetase
- multifunctional protein ADE2H1
- phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase
- Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase
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