ITPK1 antibody

Catalog No. ABIN2459840

Product Details anti-ITPK1 Antibody

Target: ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ITPK1.

Application Details

Application Notes: ITPK1 antibody can be used for detection of ITPK1 by ELISA at 1:312500. ITPK1 antibody can be used for detection of ITPK1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store ITPK1 antibody at -20 °C.

Target Details for ITPK1

Target: ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))

Alternative Name: ITPK1 (ITPK1 Products)

Synonyms: ITRPK1 antibody, BC031182 antibody, wu:fj15d08 antibody, zgc:56075 antibody, inositol-tetrakisphosphate 1-kinase antibody, inositol 1,3,4-triphosphate 5/6 kinase antibody, inositol-tetrakisphosphate 1-kinase L homeolog antibody, inositol-tetrakisphosphate 1-kinase a antibody, ITPK1 antibody, Itpk1 antibody, itpk1.L antibody, itpk1a antibody

Background: ITPK1 is the kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6)P4 or Ins (1,3,4)P3. It may also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins (1,3,4,5)P4 and Ins (1,3,4,6)P4 in the presence of ADP and magnesium. It probably acts as the rate-limiting enzyme of the InsP6 pathway. ITPK1 modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

Molecular Weight: 45 kDa

Gene ID: 3705

NCBI Accession: NP_055031

UniProt: Q13572