FN3KRP antibody

Catalog No. ABIN2460081

Product Details anti-FN3KRP Antibody

Target: FN3KRP (Fructosamine 3 Kinase Related Protein (FN3KRP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FN3KRP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FN3KRP.

Application Details

Application Notes: FN3KRP antibody can be used for detection of FN3KRP by ELISA at 1:1562500. FN3KRP antibody can be used for detection of FN3KRP by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store FN3KRP antibody at -20 °C.

Target Details for FN3KRP

Target: FN3KRP (Fructosamine 3 Kinase Related Protein (FN3KRP))

Alternative Name: FN3KRP (FN3KRP Products)

Synonyms: FN3KL antibody, FN3K-RP antibody, fn3k antibody, fn3kl antibody, MGC145992 antibody, DKFZP469K211 antibody, RGD1304570 antibody, zgc:101634 antibody, fructosamine 3 kinase related protein antibody, fructosamine-3-kinase-related protein antibody, FN3KRP antibody, Fn3krp antibody, fn3krp antibody

Background: FN3KRP phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.FN3KRP and FN3K (MIM 608425) protect proteins from nonenzymatic glycation by phosphorylating the modified amino acid. This phosphorylation destabilizes the sugar-amine linkage and leads to spontaneous decomposition (Conner et al., 2004 [PubMed 15381090]).

Molecular Weight: 34 kDa

Gene ID: 79672

NCBI Accession: NP_078895

UniProt: Q9HA64