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FN3KRP antibody (N-Term)

FN3KRP Reactivity: Human, Mouse, Rat, Cow, Rabbit, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2787771
  • Target See all FN3KRP Antibodies
    FN3KRP (Fructosamine 3 Kinase Related Protein (FN3KRP))
    Binding Specificity
    • 2
    • 1
    • 1
    N-Term
    Reactivity
    Human, Mouse, Rat, Cow, Rabbit, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse
    Host
    • 14
    • 1
    Rabbit
    Clonality
    • 15
    Polyclonal
    Conjugate
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FN3KRP antibody is un-conjugated
    Application
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    MDPGDPAGDP AAGERHRMGR DPLLLLQALQ TLWSTRERKQ LREEAWRGFA
    Predicted Reactivity
    Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 93%, Zebrafish: 79%
    Characteristics
    This is a rabbit polyclonal antibody against FN3KRP. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human FN3KRP
    Top Product
    Discover our top product FN3KRP Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 309 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Szwergold, Manevich, Payne, Loomes: "Fructosamine-3-kinase-related-protein phosphorylates glucitolamines on the C-4 hydroxyl: novel substrate specificity of an enigmatic enzyme." in: Biochemical and biophysical research communications, Vol. 361, Issue 4, pp. 870-5, (2007) (PubMed).

  • Target
    FN3KRP (Fructosamine 3 Kinase Related Protein (FN3KRP))
    Alternative Name
    FN3KRP (FN3KRP Products)
    Synonyms
    FN3KL antibody, FN3K-RP antibody, fn3k antibody, fn3kl antibody, MGC145992 antibody, DKFZP469K211 antibody, RGD1304570 antibody, zgc:101634 antibody, fructosamine 3 kinase related protein antibody, fructosamine-3-kinase-related protein antibody, FN3KRP antibody, Fn3krp antibody, fn3krp antibody
    Background
    FN3KRP phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.FN3KRP and FN3K (MIM 608425) protect proteins from nonenzymatic glycation by phosphorylating the modified amino acid. This phosphorylation destabilizes the sugar-amine linkage and leads to spontaneous decomposition (Conner et al., 2004 [PubMed 15381090]).[supplied by OMIM].
    Alias Symbols: FLJ12171, FN3KL
    Protein Interaction Partner: APP, CUL3, CUL4B, UBC, USP43,
    Protein Size: 309
    Molecular Weight
    34 kDa
    Gene ID
    79672
    NCBI Accession
    NM_024619, NP_078895
    UniProt
    Q9HA64
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