ZMPSTE24 antibody

Catalog No. ABIN2462996

Product Details anti-ZMPSTE24 Antibody

Target: ZMPSTE24 (Zmpste24) (Zinc Metalloproteinase, Ste24 (Zmpste24))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZMPSTE24 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZMPSTE24.

Application Details

Application Notes: ZMPSTE24 antibody can be used for detection of ZMPSTE24 by ELISA at 1:312500. ZMPSTE24 antibody can be used for detection of ZMPSTE24 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store ZMPSTE24 antibody at -20 °C.

Target Details for ZMPSTE24

Target: ZMPSTE24 (Zmpste24) (Zinc Metalloproteinase, Ste24 (Zmpste24))

Alternative Name: ZMPSTE24 (Zmpste24 Products)

Synonyms: DDBDRAFT_0189115 antibody, DDBDRAFT_0237846 antibody, DDB_0189115 antibody, DDB_0237846 antibody, F2N1.21 antibody, F2N1_21 antibody, STE24 antibody, FACE-1 antibody, FACE1 antibody, HGPS antibody, PRO1 antibody, Ste24p antibody, A530043O15Rik antibody, D030046F19 antibody, Face-1 antibody, MADB antibody, fi45a02 antibody, wu:fi45a02 antibody, zgc:55655 antibody, zinc metallopeptidase STE24 antibody, zinc metallopeptidase STE24 L homeolog antibody, CAAX prenyl protease antibody, Peptidase family M48 family protein antibody, zinc metallopeptidase, STE24 antibody, zinc metallopeptidase, STE24 homolog antibody, ZMPSTE24 antibody, zmpste24.L antibody, zmpste24 antibody, ATSTE24 antibody, Zmpste24 antibody

Background: ZMPSTE24 is a member of the peptidase M48A family. This protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in ZMPSTE24 gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.The protein encoded by this gene is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.

Molecular Weight: 55 kDa

Gene ID: 10269

NCBI Accession: NP_005848

UniProt: O75844