IL-24 antibody (AA 100-150)

Catalog No. ABIN2469581

Product Details anti-IL-24 Antibody

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Binding Specificity: AA 100-150

Reactivity: Human, Monkey, Gorilla

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-24 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: Protein G Column

Immunogen: IL - 24 antibody was raised against a portion of amino acids 100 - 150 of IL - 24 (Human).

Isotype: IgG

Application Details

Application Notes: IL-24 antibody can be used in ELISA starting at 1:2500 - 1:10000, Western Blot starting at 1:250 - 1:1000, immunohistochemistry starting at 5 μg/mL, immunocytochemistry, and immunofluorescence starting at 1:100 - 1:500.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.2 % gelatin, 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store IL-24 antibody at 4 °C or -20 °C.

Target Details for IL-24

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Alternative Name: IL-24 (IL24 Products)

Synonyms: C49A antibody, FISP antibody, IL10B antibody, MDA7 antibody, MOB5 antibody, ST16 antibody, Mda7 antibody, St16 antibody, Mda-7 antibody, IL24 antibody, interleukin 24 antibody, IL24 antibody, Il24 antibody

Background: Interleukin 24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. The human IL-24 is secreted by activated peripheral blood mononuclear cells and binds two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 resulting in the activation of JAK/STAT signaling pathways. Mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.

Gene ID: 11009

UniProt: Q13007

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Autophagy