SCN3B antibody (AA 1-215) (PE)
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- Target See all SCN3B Antibodies
- SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))
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Binding Specificity
- AA 1-215
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Reactivity
- Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This SCN3B antibody is conjugated to PE
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Application
- Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- Detects ~40 kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Protein G Purified
- Immunogen
- Fusion protein amino acids 1-215 (full-length) of rat NavBeta3
- Clone
- S396-29
- Isotype
- IgG2b
- Top Product
- Discover our top product SCN3B Primary Antibody
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- Application Notes
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- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- Comment
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A 1:100 dilution of ABIN2485591 was sufficient for detection of NavBeta3 in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Conjugated antibodies should be stored at 4°C
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- Target
- SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))
- Alternative Name
- NaVbeta3 (SCN3B Products)
- Synonyms
- 1110001K16Rik antibody, 4833414B02Rik antibody, Scnb3 antibody, HSA243396 antibody, SCNB3 antibody, sodium voltage-gated channel beta subunit 3 antibody, sodium channel, voltage-gated, type III, beta antibody, SCN3B antibody, Scn3b antibody
- Background
- Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).
- Gene ID
- 245956
- NCBI Accession
- NP_620797
- UniProt
- Q9JK00
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