Abeta 1-42 antibody

Catalog No. ABIN249343

Product Details anti-Abeta 1-42 Antibody

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Abeta 1-42 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Dot Blot (DB), Immunolocalization (IL)

Cross-Reactivity (Details): Not reactive in: no confirmed exceptions from predicted reactivity known in the moment

Predicted Reactivity: bovine, chicken, dog, porcine, rabbit

Characteristics: Expected / apparent Molecular Weight of the Antigene: 4.5 kDa

Purification: serum

Immunogen: synthetic peptide chosen from human Abeta (1-42) protein. Amino acid sequence: D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V-I-A

Application Details

Application Notes: 1:1000 (DB), 1:3000 (ELISA), 1-2 μg/mL (IL)

Comment:

the antibody can detect Abeta (1-42), Abeta (1-28) Abeta (1-20) and Abeta (1-17). This product exhibits a low reactivity to monomeric Abeta (1-42) as determined by SDS-PAGE and Western blotting.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: For reconstitution add 100 μL of sterile water.

Handling Advice: Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
Once reconstituted make aliquots to avoid repreated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: store lyophilized/reconstituted at -20°C, once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

References for anti-Abeta 1-42 antibody (ABIN249343)

Lindhagen-Persson, Brännström, Vestling, Steinitz, Olofsson: "Amyloid-? oligomer specificity mediated by the IgM isotype--implications for a specific protective mechanism exerted by endogenous auto-antibodies." in: PLoS ONE, Vol. 5, Issue 11, pp. e13928, (2010) (PubMed).

Target Details for Abeta 1-42

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Alternative Name: Amyloid-beta 42 protein (Abeta (1-42)) (Abeta 1-42 Products)

Synonyms: amyloid beta precursor protein antibody, App antibody, APP antibody

Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of the amyloid precursor protein P05067

Molecular Weight: 4.5 kDa