Abeta 1-42 antibody (AA 1-42)

Catalog No. ABIN725015

Product Details anti-Abeta 1-42 Antibody

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Binding Specificity: AA 1-42

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Abeta 1-42 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Predicted Reactivity: Dog,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide of human beta-Amyloid(1-42)

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Abeta 1-42 antibody (ABIN725015)

Behairi, Belkhelfa, Rafa, Labsi, Deghbar, Bouzid, Mesbah-Amroun, Touil-Boukoffa: "All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats." in: Journal of neuroimmunology, Vol. 300, pp. 21-29, (2017) (PubMed).

Vinothkumar, Kedharnath, Krishnakumar, Sreedhar, Preethikrishnan, Dinesh, Sundaram, Balakrishnan, Shivashekar, Sureshkumar, Venkataraman: "Abnormal amyloid β42expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease." in: BBA clinical, Vol. 8, pp. 20-27, (2017) (PubMed).

Tian, Guo, Wu, Ma, Zhao: "Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats." in: Cellular and molecular neurobiology, (2015) (PubMed).

Wang, Wang: "Studying the relationship between cell cycle and Alzheimer's disease by gold nanoparticle probes." in: Analytical biochemistry, Vol. 489, pp. 32-7, (2015) (PubMed).

Li, Dai, Sun, Xiang, Yang, Dai, Zhang: "Neuroglobin Attenuates Beta Amyloid-Induced Apoptosis Through Inhibiting Caspases Activity by Activating PI3K/Akt Signaling Pathway." in: Journal of molecular neuroscience : MN, (2015) (PubMed).

Kang, Li, Xing, Li, Su, Fan, Wang, Cui: "Dihydrotestosterone treatment delays the conversion from mild cognitive impairment to Alzheimer's disease in SAMP8 mice." in: Hormones and behavior, Vol. 65, Issue 5, pp. 505-15, (2014) (PubMed).

Zhou, Luo, Dai: "Axonal and Dendritic Changes are Associated with Diabetic Encephalopathy in Rats: An Important Risk Factor for Alzheimer's Disease." in: Journal of Alzheimer's disease : JAD, (2013) (PubMed).

Zhang, Gao, Luo, Chen, Gao, Gao, Zhou, Dai: "Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease." in: PLoS ONE, Vol. 7, Issue 3, pp. e33722, (2012) (PubMed).

Xiao, He, Wang, Luo, Sun, Zhou, Guan, Lucassen, Dai: "The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease." in: Neuroscience bulletin, Vol. 27, Issue 5, pp. 287-99, (2011) (PubMed).

Target Details for Abeta 1-42

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Alternative Name: beta Amyloid 1-42 (Abeta 1-42 Products)

Synonyms: amyloid beta precursor protein antibody, App antibody, APP antibody

Background:

The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.

Subcellular location: Cytoplasm, Cell membrane, Extracellular matrix

Synonyms: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, Amyloid beta A4 protein, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, A4

Gene ID: 351

UniProt: P05067