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CD3 epsilon antibody
CD3E
Reactivity: Mouse
FACS, WB, IHC, IF, IP, Func
Host: Hamster
Monoclonal
145-2C11
unconjugated
Product Details anti-CD3 epsilon Antibody
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Target
See all CD3 epsilon (CD3E) Antibodies
CD3 epsilon (CD3E)
Reactivity
All reactivities for CD3 epsilon antibodies
Mouse
Host
All hosts for CD3 epsilon antibodies
Hamster
Clonality
All clonalities for CD3 epsilon antibodies
Monoclonal
Conjugate
All conjugates for CD3 epsilon antibodies
This CD3 epsilon antibody is un-conjugated
Application
All applications for CD3 epsilon antibodies
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Functional Studies (Func)
Specificity
The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex.
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clone
145-2C11
Isotype
IgG
Top Product
Discover our top product CD3E Primary Antibody
Alternatives
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anti-CD3 epsilon (CD3E) (AA 156-168), (Cytoplasmic Domain) antibody
CD3E
Reactivity: Human, Rat, Pig, Rabbit, Cow, Horse, Guinea Pig, Chicken
FACS, WB, IF
Host: Mouse
Monoclonal
PC3-188A
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.5 mg/mL
Buffer
Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Storage
4 °C
Storage Comment
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Target Details for CD3 epsilon
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Target
CD3 epsilon (CD3E)
Alternative Name
CD3e (CD3E Products )
Synonyms
cd3e antibody, CD3E antibody, t3e antibody, tcre antibody, AI504783 antibody, CD3 antibody, CD3epsilon antibody, T3e antibody, T3E antibody, TCRE antibody, CD3e molecule antibody, CD3 antigen, epsilon polypeptide antibody, cd3e antibody, CD3E antibody, Cd3e antibody
Background
The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex. Together with the γ and δ subunits of CD3, the ε subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the ε chain enhances the antigen recognition.The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes. The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.
Gene ID
12501
UniProt
P22646
Pathways
TCR Signaling , CXCR4-mediated Signaling Events , Ubiquitin Proteasome Pathway
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