VTI1B antibody

Catalog No. ABIN2568531

Product Details anti-VTI1B Antibody

Target: VTI1B (Vesicle Transport through Interaction with T-SNAREs Homolog 1B (VTI1B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VTI1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: VTI1b antibody is human, mouse and rat reactive. At least three isoforms of VTI1a are known to exist, this antibody will detect all three isoforms. VTI1b antibody is predicted to not cross-react with VTI1a.

Purification: VTI1b antibody is affinity chromatography purified via peptide column.

Immunogen: VTI1b antibody was raised against a 17 amino acid peptide near the center of human VTI1b.

Isotype: IgG

Application Details

Application Notes: VTI1b antibody can be used for detection of VTI1b by Western blot at 1 - 2 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: VTI1b antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: VTI1b antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for VTI1B

Target: VTI1B (Vesicle Transport through Interaction with T-SNAREs Homolog 1B (VTI1B))

Alternative Name: VTI1b (VTI1B Products)

Synonyms: VTI1 antibody, VTI1-LIKE antibody, VTI1L antibody, VTI2 antibody, v-SNARE antibody, vti1-rp1 antibody, AU015348 antibody, GES30 antibody, MVti1b antibody, SNARE antibody, Vti1-rp1 antibody, zgc:63525 antibody, VTI1B antibody, vesicle transport through interaction with t-SNAREs 1B antibody, vesicle transport through interaction with t-SNAREs 1B pseudogene antibody, VTI1B antibody, Vti1b antibody, vti1b antibody, LOC461624 antibody

Background: Vesicle transport through interaction with t-SNAREs homolog 1 (VTI1a and VTI1b) are involved in vesicular transport from the late endosomes to the trans-Golgi network (1). They are both localized in the trans-Golgi network, with VTI1a also found in the Golgi apparatus and VTI1b in endosomes (2,3). It is thought that VTI1b along with the SNARE protein VAMP8 mediates the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential process for autophagy (4).

Molecular Weight: Predicted: 14, 19, 26 kDa

Observed: 27 kDa

Gene ID: 10490

NCBI Accession: NP_006361

UniProt: Q9UEU0