NAPA
Reactivity: Human
Host: Rabbit
Polyclonal
FITC
Application Notes
Suitable for use in Western Blot: 1/5000. Positive Control: Rat brain. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
20 mM Sodium Phosphate, 150 mM Sodium Chloride, 50 % Glycerol, pH 7.5
Storage
-20 °C
Storage Comment
Store the antibody at -20 °C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
38 kDa SNAPs (soluble NSF attachment proteins), acting in concert with SNAREs (SNAP receptors) and the N-ethylmaleimide- sensitive fusion protein (NSF) are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-toendosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. alpha-SNAP (or beta-SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process.Synonyms: Alpha-soluble NSF attachment protein, NAPA, SNAP-alpha, SNAPA