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beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 485-501) antibody

Details for Product No. ABIN264995
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Antigen
Synonyms BACE1, MGC145931, bace2, MGC68881, MGC68482, BACE2, C76936, Bace, ASP2, BACE, HSPC104, zgc:77409
Epitope
AA 485-501
(20), (19), (17), (8), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(132), (67), (47), (25), (24), (24), (19), (12), (1)
Host
Rabbit
(128), (6), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(92), (54), (41), (28), (20), (15), (6), (5), (3), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN264995
368.50 $
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Immunogen Synthetic peptide corresponding to amino acids 485 to 501 of Human BACE.
Isotype IgG
Specificity This antibody Detects BACE (CT).
Purification Purified
Alternative Name BACE1
Background BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl- terminal domain of beta APP, thus generating the amyloid beta peptide.
Alternate names: ASP2, Aspartyl protease 2, BACE, BACE-1, Beta-secretase 1, Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2
Gene ID 23621
NCBI Accession NP_036236.1
UniProt P56817
Research Area Proteolysis / Ubiquitin, Alzheimer's Disease, Enzymes
Application Notes Western Blot: 0.5-1.0 µg/ml. Detects an approximately 70 kDa band. Positive Control: Human brain tissue lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline solution containing 0.02% Sodium Azide as a preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Expiry Date 12 months
Supplier Images
anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 485-501) antibody anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 485-501) antibody
Background publications Vassar, Bennett, Babu-Khan et al.: "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 735-41, 1999 (PubMed).

Yan, Bienkowski, Shuck et al.: "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity." in: Nature, Vol. 402, Issue 6761, pp. 533-7, 1999 (PubMed).

Sinha, Anderson, Barbour et al.: "Purification and cloning of amyloid precursor protein beta-secretase from human brain." in: Nature, Vol. 402, Issue 6761, pp. 537-40, 1999 (PubMed).

Hussain, Powell, Howlett et al.: "Identification of a novel aspartic protease (Asp 2) as beta-secretase." in: Molecular and cellular neurosciences, Vol. 14, Issue 6, pp. 419-27, 2000 (PubMed).

Validation Images
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