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CCR5 antibody (C-C Chemokine Receptor Type 5) (AA 6-20)

Details for Product anti-CCR5 Antibody No. ABIN265000, Supplier: Log in to see
Antigen
  • AM4-7
  • CC-CKR-5
  • CCCKR5
  • CCR-5
  • CCR5
  • CD195
  • CKR-5
  • CKR5
  • Ckr5
  • CMKBR5
  • Cmkbr5
  • GPCR
  • IDDM22
Alternatives
anti-Human CCR5 antibody for Flow Cytometry
Epitope
AA 6-20
25
23
17
15
13
13
12
11
10
9
7
6
5
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
312
75
49
8
2
1
1
Host
Rabbit
156
103
63
17
12
2
Clonality
Polyclonal
Conjugate
This CCR5 antibody is un-conjugated
35
24
14
8
7
6
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
177
164
117
44
31
30
27
17
12
8
8
6
5
4
3
2
2
2
2
2
2
1
1
1
1
1
Supplier
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Immunogen Synthetic peptide corresponding to amino acids 6 to 20 of Human CCR5.
Isotype IgG
Specificity This antibody reacts to CCR5 (6-20) (CD195).
Purification Antigen Immunoaffiinity Chromatography
Alternative Name CD195 / CCR5 (CCR5 Antibody Abstract)
Background Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors1,2. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells3,4. CCR5 is required for the infection by HIV-1, HIV-2, and SIV1,2. The b-chemokines RANTES, MIP-1a and MIP-1b are the ligands for CCR5 and prevent infection by M-tropic HIV-13-5. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells6,7. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites8. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.Synonyms: C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, CMKBR5, HIV-1 fusion coreceptor
Gene ID 1234
NCBI Accession NP_000570
UniProt P51681
Research Area CD Antigens, Surface Receptors of Immune Cells, Chemokines, Receptors
Pathways TCR Signaling
Application Notes Western Blot: 0.25 to 0.5 μg/mL. Detects an approximately 40 kDa band in THP-1 whole celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline solution containing 0.02 % Sodium Azide as a preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8 °C.
Supplier Images
 image for anti-CCR5 antibody (C-C Chemokine Receptor Type 5) (AA 6-20) (ABIN265000) anti-C-C Chemokine Receptor Type 5 (CCR5) (AA 6-20) antibody
Background publications Dimitrov: "How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity." in: Cell, Vol. 91, Issue 6, pp. 721-30, 1998

Littman: "Chemokine receptors: keys to AIDS pathogenesis?" in: Cell, Vol. 93, Issue 5, pp. 677-80, 1998

Doranz, Lu, Rucker, Zhang, Sharron, Cen, Wang, Guo, Du, Accavitti, Doms, Peiper: "Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1." in: Journal of virology, Vol. 71, Issue 9, pp. 6305-14, 1997

Deng, Liu, Ellmeier, Choe, Unutmaz, Burkhart, Di Marzio, Marmon, Sutton, Hill, Davis, Peiper, Schall, Littman, Landau: "Identification of a major co-receptor for primary isolates of HIV-1." in: Nature, Vol. 381, Issue 6584, pp. 661-6, 1996

Dragic, Litwin, Allaway, Martin, Huang, Nagashima, Cayanan, Maddon, Koup, Moore, Paxton: "HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5." in: Nature, Vol. 381, Issue 6584, pp. 667-73, 1996

Cocchi, DeVico, Garzino-Demo, Arya, Gallo, Lusso: "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells." in: Science (New York, N.Y.), Vol. 270, Issue 5243, pp. 1811-5, 1996

Wu, Gerard, Wyatt, Choe, Parolin, Ruffing, Borsetti, Cardoso, Desjardin, Newman, Gerard, Sodroski: "CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5." in: Nature, Vol. 384, Issue 6605, pp. 179-83, 1996

Trkola, Dragic, Arthos, Binley, Olson, Allaway, Cheng-Mayer, Robinson, Maddon, Moore: "CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5." in: Nature, Vol. 384, Issue 6605, pp. 184-7, 1996