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Details for Product No. ABIN265011

Visual System Homeobox 2 (VSX2) (N-Term), (AA 1-131) antibody

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Antigen
Synonyms RET1, CHX10, HOX10, MCOP2, MCOPCB3, or, Chx10, Hox10, Hox-10, VSX2, Vsx-2, alx, chx10
Epitope
»Alternatives N-Term, AA 1-131
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus)
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN265011
Quantity 0.25 mg
Price
313.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Antibody raised against a recombinant protein corresponding to amino acids 1 to 131 derived from the N terminal of the human Chx10 protein conjugated to GST.
Isotype IgG
Specificity This antibody reacts to chx 10 (N-Term).
Purification Purified
Alternative Name VSX2 / CHX10
Background Chx10 is a 46kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.
Alternate names: Ceh-10 homeodomain-containing homolog, HOX10, Homeobox protein CHX10, Visual system homeobox 2
Gene ID 12677
NCBI Accession NP_031727
UniProt Q61412
Application Notes Western Blot: 0.5-1.0 mg/ml. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Immunohistochemistry on Frozen Sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.08% Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C. Can be shipped at ambient temperature.
Expiry Date 12 months
Background publications Liu, Chen, Ploder et al.: "Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer." in: Neuron, Vol. 13, Issue 2, pp. 377-93, 1994 (PubMed).

Chen, Cepko: "Expression of Chx10 and Chx10-1 in the developing chicken retina." in: Mechanisms of development, Vol. 90, Issue 2, pp. 293-7, 2000 (PubMed).

Ferda Percin, Ploder, Yu et al.: "Human microphthalmia associated with mutations in the retinal homeobox gene CHX10." in: Nature genetics, Vol. 25, Issue 4, pp. 397-401, 2000 (PubMed).

Alternatives for antigen "Visual System Homeobox 2 (VSX2)", type "Antibodies"
Hosts (26), (11), (1)
Reactivities (25), (23), (20), (15), (13), (12), (1), (1)
Applications (28), (11), (10), (6), (3), (3), (3), (3), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (3), (2), (2), (1), (1)
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