Purinergic Receptor P2Y, G-Protein Coupled, 13 (P2RY13) antibody

Catalog No. ABIN4620374

Product Details

Target: Purinergic Receptor P2Y, G-Protein Coupled, 13 (P2RY13)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects P2Y13.

Purification: Affinity chromatography

Immunogen: Synthetic peptide derived from human GPCR94

Application Details

Application Notes: Western blot (1: 400 starting dilution).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Target Details

Target: Purinergic Receptor P2Y, G-Protein Coupled, 13 (P2RY13)

Alternative Name: P2Y13 / P2YR13 (P2RY13 Products)

Synonyms: MGC80556 antibody, MGC108160 antibody, 2010001L06Rik antibody, GPCR1 antibody, GPR94 antibody, Gpr86 antibody, P2Y13 antibody, P2yr13 antibody, SP174 antibody, GPR86 antibody, P2y13 antibody, purinergic receptor P2Y, G-protein coupled, 13 L homeolog antibody, purinergic receptor P2Y, G-protein coupled, 13 antibody, purinergic receptor P2Y13 antibody, purinergic receptor P2Y, G-protein coupled 13 antibody, p2ry13.L antibody, p2ry13 antibody, P2RY13 antibody, P2ry13 antibody

Background: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined. Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.Synonyms: FKSG77, G-protein coupled receptor 86, G-protein coupled receptor 94, GPR86, GPR94, P2Y purinoceptor 13, Purinergic receptor

Gene ID: 53829

NCBI Accession: NP_795713

UniProt: Q9BPV8

Pathways: cAMP Metabolic Process