Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1) antibody

Antigen: Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1)

Synonyms: htpG

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN265473

Additional Information

Characteristics: Synonyms: HSP90A, HSPC1, HSPCA, Heat shock 86 kDa, HSP86, NY-REN-38, Heat shock protein HSP90-alpha

Alternative name: HSP90AA1 / HSP90 alpha

Swiss-Prot: P07900

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Description: In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and Hsp90b which areencoded by separate genes. These ubiquitous and highly conserved proteins account for1-2% of all cellular proteins in most cells. Hsp90 is part of the cells powerful network ofchaperones to fight the deleterious consequences of protein unfolding caused bynonphysiological conditions. However, in the absence of stress, Hsp90 is a necessarycomponent of fundamental cellular processes such as hormone signaling and cell cyclecontrol. In this context several key regulatory proteins such as steriod receptors, cell cyclekinases involved in signal transduction and p53 have been identified as substrates ofHsp90. It has been suggested that Hsp90 acts as a capacitor for morphological evolutionby buffering widespread variation, which may affect morphogenic pathways.

Specificity: HSP90A/HSP86 (P717) antibody detects endogenous levels of HSP90A/HSP86 protein. Species: Human, Mouse, Rat. Others not tested.

Application Details

Application Notes: ELISA: 1: 40000~1: 60000. WB: 1: 500~1: 1000. IHC: 1: 50~1: 200. IP: 1: 50~1: 200. IF: 1: 50~1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1,0 mg/ml

Purification: Aff - Purified

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Storage: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Restrictions: For Research Use only