ARTC2 Nanobody antibody
Reactivity: Mouse
ICFC
Host: Mouse
Monoclonal
S-16a
unconjugated
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- Target
- ARTC2 Nanobody
- Reactivity
- Mouse
- Host
- Mouse
- Clonality
- Monoclonal
- Application
- Intracellular Flow Cytometry (ICFC)
- Clone
- S-16a
- Isotype
- Ig Fraction
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Treg-Protector ™ is sterilized by filtration through a 0.22 μm membrane and contains no preservatives.
- Preservative
- Without preservative
- Handling Advice
- Do not freeze. Keep sterile.
- Storage
- 4 °C
- Storage Comment
- Store between 2°C and 8°C.
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- Target
- ARTC2 Nanobody
- Background
- ARTC2, also known as ART2.2, is a 35 kD, GPI-anchored, and cell surface ADP-ribosyltransferase that is highly expressed by regulatory T cells (Tregs) and natural killer T (NKT) cells. ARTC2 is enzymatically active at 4 °C. Through the ribosylation of the ion channel P2X7, ARTC2 mediates NAD+-induced cell death (NICD) and the proteolytic shedding of CD27 and CD62L. Blocking the activity ARTC2 with Treg-Protector™ improves the recovery of Tregs and NKT cells during their isolation from lymphatic and peripheral tissues.
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