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ITGAL antibody (Alexa Fluor 488)
ITGAL
Reactivity: Human
FACS
Host: Mouse
Monoclonal
m24
Alexa Fluor 488
Product Details anti-ITGAL Antibody (Alexa Fluor 488)
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Target
See all ITGAL Antibodies
ITGAL
(Integrin alpha-L (ITGAL))
Reactivity
All reactivities for ITGAL antibodies
Human
Host
All hosts for ITGAL antibodies
Mouse
Clonality
All clonalities for ITGAL antibodies
Monoclonal
Conjugate
All conjugates for ITGAL antibodies
This ITGAL antibody is conjugated to Alexa Fluor 488
Application
All applications for ITGAL antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
Clone
M24
Isotype
IgG1 kappa
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C
Target Details for ITGAL
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Target
ITGAL
(Integrin alpha-L (ITGAL))
Alternative Name
CD11a/CD18 (ITGAL Products )
Synonyms
CD11A antibody, LFA-1 antibody, LFA1A antibody, (p180) antibody, Cd11a antibody, LFA-1A antibody, Ly-15 antibody, Ly-21 antibody, CD11a antibody, ITGAL antibody, integrin subunit alpha L antibody, integrin alpha L antibody, ITGAL antibody, Itgal antibody
Background
CD11/CD18 belongs to the integrin family of proteins. It is heterodimeric cell surface receptor expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and αXβ2, respectively, and plays an important role in leukocyte adhesion. CD11/CD18 complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. Clone m24 binds the extended/open high affinity conformation of CD11a/CD18. The antibody can be used as a reporter of the activation state of the integrin receptor in response to exposure to Mg2+ or Mn2+.
Pathways
Activated T Cell Proliferation , Integrin Complex
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