DR3/LARD (TNFRSF25)
(Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))
Reactivity
Mouse
Host
Armenian Hamster
Clonality
Monoclonal
Conjugate
This DR3/LARD antibody is conjugated to PE
Application
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
DR3, also known as TNFRSF25, lymphocyte-associated receptor of death (LARD), WSL-1, TRAMP, TR3 and APO3, is a 55 kD glycoprotein belonging to the TNF receptor superfamily (TNFRSF). TNFSF25 is expressed at low level on CD4-positive, CD8-positive T cells and NKT cells. It has been shown to stimulate NF-κB activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domains containing adaptor proteins. Recently, it has been shown that TNFRSF25 is also expressed on Treg cells and regulates Treg proliferation.