IL-27/IL-35 EBI3 Subunit (Dimer), (Heterodimer), (Monomer) antibody (PE)
Reactivity: Human
FACS
Host: Mouse
Monoclonal
B032F6
PE
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- Target
- IL-27/IL-35 EBI3 Subunit
- Binding Specificity
- Dimer, Heterodimer, Monomer
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Monoclonal
- Conjugate
- PE
- Application
- Flow Cytometry (FACS)
- Purification
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- Clone
- B032F6
- Isotype
- IgG2b kappa
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from prolonged exposure to light. Do not freeze.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- IL-27/IL-35 EBI3 Subunit
- Alternative Name
- IL-27/IL-35 EBI3
- Background
- Epstein-Barr virus induced gene-3, also known as EBI3, is an IL-12 p40-related protein that can heterodimerize with IL-12 p35 to form IL-35, or with an IL-12 p35-related protein, p28, to form IL-27. It is produced by antigen-presenting cells such as B cells, monocytes, and dendritic cells following stimulation through TLR. It can regulate T cell differentiation and proliferation. Both IL-27 and IL-35 are anti-inflammatory cytokines that are able to inhibit Th17 generation, promote Th1 diferentiation, increase cytolytic potential of CD8+ T cells, and impact B cell differentiation and Ig production.
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