BIN1 antibody

Catalog No. ABIN2664071

Product Details anti-BIN1 Antibody

Target: BIN1 (Bridging Integrator 1 (BIN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BIN1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 99D

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for BIN1

Target: BIN1 (Bridging Integrator 1 (BIN1))

Alternative Name: Bin1 (BIN1 Products)

Synonyms: bin1 antibody, MGC53185 antibody, amph2 antibody, amphl antibody, sh3p9 antibody, MGC76187 antibody, cb57 antibody, zgc:86701 antibody, BIN1 antibody, AMPH2 antibody, AMPHL antibody, SH3P9 antibody, ALP-1 antibody, Amphl antibody, BRAMP-2 antibody, bridging integrator 1 antibody, bridging integrator 1 S homeolog antibody, bridging integrator 1b antibody, BIN1 antibody, bin1.S antibody, bin1 antibody, bin1b antibody, Bin1 antibody

Background: Bridging integrator 1 (Bin1) is a conserved member of the BAR family of genes that have been implicated in diverse cellular processes including endocytosis, cell polarity, programmed cell death, and stress signaling. It is involved in membrane remodeling and is one of the important genes in predicting risk for Alzheimer's disease (AD). Alternative splicing of the gene results in ten transcript variants. Isoforms 1-7 are expressed predominantly in the central nervous system. Isoform 8 is expressed specifically in muscle, and defects in BIN1 cause autosomal recessive myotubular myopathy. Isoforms 9 and 10 are ubiquitously expressed and may act as tumor repressors.