CD131 antibody

Catalog No. ABIN2664200

Product Details anti-CD131 Antibody

Target: CD131 (CSF2RB) (Colony Stimulating Factor 2 Receptor, Beta (CSF2RB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD131 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 1C1

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CD131

Target: CD131 (CSF2RB) (Colony Stimulating Factor 2 Receptor, Beta (CSF2RB))

Alternative Name: CD131 (CSF2RB Products)

Synonyms: Csf2rb1 antibody, CSF2RB antibody, cd131 antibody, cdw131 antibody, il3rb antibody, il5rb antibody, il-3rbc antibody, CD131 antibody, CDw131 antibody, IL3RB antibody, IL5RB antibody, SMDP5 antibody, AI848964 antibody, AIC2B antibody, Bc antibody, Csfgmrb antibody, Il3r antibody, Il3rb antibody, Il3rb1 antibody, Il5rb antibody, colony stimulating factor 2 receptor beta common subunit antibody, colony stimulating factor 2 receptor beta common subunit S homeolog antibody, cytokine receptor common subunit beta-like antibody, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) antibody, CSF2RB antibody, Csf2rb antibody, csf2rb.S antibody, CRCBL antibody, csf2rb antibody

Background: CD131, also known as the IL-3R common β subunit (βC), is a 95-120 kD type I transmembrane glycoprotein and belongs to the Ig superfamily. The common β subunit associates with the specific α subunits of IL-3 receptor, IL-5 receptor and GM-CSF receptor to form high affinity receptors for these cytokines. These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth/activation of eosinophils and in the inflammatory response. The 1C1 antibody is a non-blocking antibody.

Pathways: JAK-STAT Signaling