CD180 antibody
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- Target See all CD180 Antibodies
- CD180 (CD180 Molecule (CD180))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD180 antibody is un-conjugated
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Application
- Flow Cytometry (FACS)
- Cross-Reactivity
- Baboon, Cynomolgus, Rhesus Monkey
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- MHR73-11
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD180 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- CD180 (CD180 Molecule (CD180))
- Alternative Name
- CD180 (CD180 Products)
- Synonyms
- Ly78 antibody, CD180 antibody, LY64 antibody, RP105 antibody, F630107B15 antibody, CD180 molecule antibody, CD180 antigen antibody, Cd180 antibody, CD180 antibody
- Background
- CD180, also known as RP105, is a 105 kD member of the toll-like receptor (TLR) family and is expressed on most B cells, monocytes/macrophages and dendritic cells. The TLR family's structural characteristics are critically involved in protein-protein signaling interactions leading to the activation of the innate immune system. Additionally, MD-1, a secretory protein, associates with CD180 (RP105) at the cell surface and this complex, in conjunction with TLR4, recognizes bacterial LPS. The human CD180 (RP105) gene maps to 5q12. The MHR73-11 antibody is able to activate B cells and to protect against irradiation- or dexamethasone-induced apoptosis.
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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