KIF11 antibody

Catalog No. ABIN2664936

Product Details anti-KIF11 Antibody

Target: KIF11 (Kinesin Family Member 11 (KIF11))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This KIF11 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 10C7-Eg5

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide at 0.5 mg/mL.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for KIF11

Target: KIF11 (Kinesin Family Member 11 (KIF11))

Alternative Name: Eg5 (KIF11 Products)

Synonyms: EG5 antibody, HKSP antibody, KNSL1 antibody, MCLMR antibody, TRIP5 antibody, Eg5 antibody, Kif8 antibody, Kifl1 antibody, Knsl1 antibody, F2H17.19 antibody, F2H17_19 antibody, DDBDRAFT_0189194 antibody, DDBDRAFT_0201556 antibody, DDB_0189194 antibody, DDB_0201556 antibody, XLEg5K1 antibody, XlEg5 antibody, cos2 antibody, costal2 antibody, eg5 antibody, hksp antibody, kif11 antibody, kif11-a antibody, kif11-b antibody, kif11b antibody, knsl1 antibody, trip5 antibody, Cos2 antibody, Costal2 antibody, XLEg5K2 antibody, kif11a antibody, kinesin family member 11 antibody, P-loop containing nucleoside triphosphate hydrolases superfamily protein antibody, kinesin family member 11 S homeolog antibody, kinesin family member 11 L homeolog antibody, KIF11 antibody, Kif11 antibody, AT2G36200 antibody, kif11 antibody, kif11.S antibody, kif11.L antibody

Background: Eg5 (also known as kinesin-like protein KIF11, kinesin-related motor protein Eg5, kinesin-like spindle protein HKSP, and thyroid receptor interacting protein 5 (TRIP5)) is a 119 kD kinesin-like protein family, BimC subfamily. This protein is a catalytic kinesin motor with coiled-coil and Smc domains. Eg5 is localized at the centrosomes, spindle microtubules, and intracellular bridge. This motor protein is required for establishing the bipolar spindle. hEg5 is modified by phosphorylation on Thr927 by Cdc2 to allow association with the spindle apparatus. Eg5 has been shown to interact with the thyroid hormone receptor in presence of thyroid hormone and Cdc2. The 10C7/Eg5 monoclonal antibody has been shown to react with human and mouse Eg5 by Western blot.