IRF6 antibody
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- Target See all IRF6 Antibodies
- IRF6 (Interferon Regulatory Factor 6 (IRF6))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This IRF6 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- 14B2C16
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product IRF6 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- IRF6 (Interferon Regulatory Factor 6 (IRF6))
- Alternative Name
- IRF6 (IRF6 Products)
- Synonyms
- IRF6 antibody, lps antibody, pit antibody, pps antibody, vws antibody, ofc6 antibody, xIRF-6 antibody, DKFZp469E012 antibody, LPS antibody, OFC6 antibody, PIT antibody, PPS antibody, PPS1 antibody, VWS antibody, VWS1 antibody, zgc:63500 antibody, AI876454 antibody, E230028I05Rik antibody, mirf6 antibody, interferon regulatory factor 6 antibody, interferon regulatory factor 6 S homeolog antibody, IRF6 antibody, irf6 antibody, irf6.S antibody, Irf6 antibody
- Background
- IRF6 is a member of the IRF family of transcription factors, which are based on the presence of the conserved IRF tryptophan pentad repeat DNA-binding domain. Unlike other IRF transcription factors, IRF6 is not involved in the expression of interferon genes and doesn't seem to be involved in innate immunity. Data suggests that IRF6 is necessary for appropriate epidermal differentiation and development. Mutations of IRF6 are associated with human craniofacial developmental defects such as cleft lip, palate, tooth agenesis, Van der Woude syndrome, and popliteal pterygium syndrome. IRF6-deficient mice display severe morphological defects in skin and limbs, and result in perinatal lethality as well.
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