TCR V Gamma1.1/Cr4 antibody
Reactivity: Mouse
FACS
Host: Armenian Hamster
Monoclonal
2-11
unconjugated
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- Target
- TCR V Gamma1.1/Cr4
- Reactivity
- Mouse
- Host
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Armenian Hamster
- Clonality
- Monoclonal
- Application
- Flow Cytometry (FACS)
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- 2-11
- Isotype
- IgG
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
-
- Target
- TCR V Gamma1.1/Cr4
- Background
- T cell receptor (TCR) is a heterodimer consisting of an α and β chain (TCR α/β) or a γ and δ chain (TCR γ/δ). TCR associates with CD3 to form a CD3/TCR complex. The CD3/TCR plays a key role in antigen recognition, signal transduction, and T cell activation. TCR Vγ1.1 (Garman nomenclature) is also called TCR Vγ1 (Tonegawa nomenclature). The Vγ1 gene almost exclusively rearranges to the Jγ4-Cγ 4 gene. Vγ1- Jγ4-Cγ4 expressing cells constitute a major population of γ/δ T cells in thymus and peripheral lymphoid organs in adult mice, but they are only composed of a minor population of γ/δ T cells during fetal and early postnatal life. Vγ1 T cell development can happen in thymus-dependent and thymus-independent manners. Further studies have shown that the antibody 2.11 recognized epitote is located in Cr4 domain.
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