CD300a antibody
-
- Target See all CD300a (CD300A) Antibodies
- CD300a (CD300A)
-
Reactivity
- Mouse
-
Host
- Rat
-
Clonality
- Monoclonal
-
Conjugate
- This CD300a antibody is un-conjugated
-
Application
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Brand
- Ultra-LEAF™
- Purification
- The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
-
Endotoxin level is <0.01 EU/μg of the protein (<0.001 ng/μg of the protein) as determined by the LAL test.
- Clone
- TX41
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product CD300A Primary Antibody
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Preservative
- Azide free
- Handling Advice
- This Ultra-LEAF™ solution contains no preservative, handle under aseptic conditions
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
-
- Target
- CD300a (CD300A)
- Alternative Name
- CD300a (CD300A Products)
- Synonyms
- CD300L-B1 antibody, CD300A antibody, clm8 antibody, B230315M08Rik antibody, Clm8 antibody, LMIR1 antibody, MAIR-I antibody, MAIR-Ia antibody, MMAC8 antibody, Pigr4 antibody, mcpir1 antibody, CLM-8 antibody, CMRF-35-H9 antibody, CMRF-35H antibody, CMRF35-H antibody, CMRF35-H9 antibody, CMRF35H antibody, CMRF35H9 antibody, IGSF12 antibody, IRC1 antibody, IRC1/IRC2 antibody, IRC2 antibody, IRp60 antibody, CD300 molecule like family member g antibody, CD300a molecule antibody, CMRF35-like molecule 8 antibody, CD300A molecule antibody, Cd300a molecule antibody, CD300LG antibody, CD300A antibody, LOC483289 antibody, clm8 antibody, Cd300a antibody
- Background
- CD300 receptors are a group of type I transmembrane proteins, which belong to the Ig superfamily. In mice, nine members have been reported with different nomenclature systems, such as myeloid-associated Ig-like receptor (MAIR), leukocyte mono-Ig-like receptor (LMIR), DC-derived Ig-like receptor (DIgR), and CMRF-35-like molecule (CLM). The CD300 Molecules act as either activating or inhibitory receptors through interactions with adaptor molecules, such as PAD12, DAP10, and FcRγ. CD300a is an inhibitory receptor that is mainly expressed on peripheral eosinophils, mast cells, neutrophils, dendritic cells, macrophages, and some B cells. Cross-linking CD300a by an antibody can induce phosphorylation of tyrosine residues in the cytoplasmic domain, which results in recruitment of phosphatases SHIP, SHP1 and SHP2 and inhibition of cell activation.
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
-