IL16 antibody (Interleukin 16)

Details for Product anti-IL16 Antibody No. ABIN2666009, Supplier: Log in to see
Antigen
  • IL16
  • LCF
  • NIL16
  • PRIL16
  • prIL-16
  • mKIAA4048
  • IL-16
  • interleukin 16
  • interleukin 16 (lymphocyte chemoattractant factor)
  • IL16
  • Il16
Reactivity
Human
197
40
29
3
2
2
1
1
1
Host
Mouse
121
89
4
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This IL16 antibody is un-conjugated
11
5
3
3
3
3
3
3
3
3
3
2
1
1
1
Application
Flow Cytometry (FACS)
130
105
42
35
19
19
17
16
13
7
6
5
4
2
2
2
2
2
1
1
Options
Supplier
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Supplier Product No.
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Brand Ultra-LEAF™
Immunogen AA 615 to 630 (RRKSLQSKETTAAGDS) of IL-16,615 to630 (RRKSLQSKETTAAGDS) of IL-16
Clone 14-1
Isotype IgG2a
Cross-Reactivity Mouse (Murine)
Purification The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Sterility 0.2 μm filtered
Endotoxin Level

Endotoxin level is <0.01 EU/μg of the protein (<0.001 ng/μg of the protein) as determined by the LAL test.

Alternative Name IL-16 (IL16 Antibody Abstract)
Background Interleukin-16 is a proinflammatory cytokine synthesized as a 68 kD precursor molecule (pro-IL-16). After cleavage of pro-IL-16 by caspase-3, IL-16 is released as a 12 kD protein, but its biologic activities are exerted by a tetramer. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. On T cells, IL-16 upregulates CD25 and class II expression, and also inhibits HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. IL-16 is expressed by lymphocytes, macrophages, eosinophils, mast cells, epithelial cells, and fibroblasts. CD4 and CD9 are the receptors of IL-16.
Research Area Signaling, Cytokines, Immunology, Virology, Inflammation, Cancer
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Preservative Azide free
Handling Advice This Ultra-LEAF™ solution contains no preservative, handle under aseptic conditions
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.
Supplier Images
Flow Cytometry (FACS) image for anti-Interleukin 16 (IL16) antibody (ABIN2666009) anti-Interleukin 16 (IL16) antibody
Background publications Bellon, Baydoun, Yao, Nicot: "HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes." in: Blood, Vol. 115, Issue 12, pp. 2441-8, 2010 (PubMed).

Cruikshank, Little: "lnterleukin-16: the ins and outs of regulating T-cell activation." in: Critical reviews in immunology, Vol. 28, Issue 6, pp. 467-83, 2009 (PubMed).

Rofani, Luchetti, Testa, Lasorella, Isacchi, Bottazzo, Berardi: "IL-16 can synergize with early acting cytokines to expand ex vivo CD34+ isolated from cord blood." in: Stem cells and development, Vol. 18, Issue 4, pp. 671-82, 2009 (PubMed).

Gu, Lewis, Deere, Groome, Wang: "Elevated maternal IL-16 levels, enhanced IL-16 expressions in endothelium and leukocytes, and increased IL-16 production by placental trophoblasts in women with preeclampsia." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 6, pp. 4418-22, 2008 (PubMed).

McFadden, Morgan, Rahangdale, Green, Yamasaki, Center, Cruikshank: "Preferential migration of T regulatory cells induced by IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 10, pp. 6439-45, 2007 (PubMed).

Qi, Wang, Mandadi, Tanaka, Roufogalis, Madigan, Lai, Yan, Chong, Stevens, Krilis: "Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor." in: Blood, Vol. 107, Issue 1, pp. 135-42, 2005 (PubMed).

Ren, Zhan, Martens, Lee, Center, Hanson, Kornfeld: "Pro-IL-16 regulation in activated murine CD4+ lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 5, pp. 2738-45, 2005 (PubMed).

Stoitzner, Ratzinger, Koch, Janke, Schöller, Kaser, Tilg, Cruikshank, Fritsch, Romani: "Interleukin-16 supports the migration of Langerhans cells, partly in a CD4-independent way." in: The Journal of investigative dermatology, Vol. 116, Issue 5, pp. 641-9, 2001 (PubMed).

Chupp, Wright, Wu, Vallen-Mashikian, Cruikshank, Center, Kornfeld, Berman: "Tissue and T cell distribution of precursor and mature IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 6, pp. 3114-9, 1998 (PubMed).

Keane, Nicoll, Kim, Wu, Cruikshank, Brazer, Natke, Zhang, Center, Kornfeld: "Conservation of structure and function between human and murine IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 12, pp. 5945-54, 1998 (PubMed).

Cruikshank, Center, Nisar, Wu, Natke, Theodore, Kornfeld: "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 5109-13, 1994 (PubMed).

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