KIR3DL1 antibody

Catalog No. ABIN2689859

Product Details anti-KIR3DL1 Antibody

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KIR3DL1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with the killer cell inhibitory receptor (KIR), NKB1, a 70 kDa glycoprotein, member of the Ig superfamily, expressed on a subset of natural killer cells and a small subset of T cells. Expression of NKB1 has been observed to vary among individuals. KIR molecules specifically recognize a certain group of HLA class I antigens. Interaction of NKB1 with specific HLA-B antigen on a target cell inhibits cell mediated cytotxicity, possibly by delivering a negative signal preventing lymphocyte activation. It is suggested that this MHC class I-KIR interaction works as a regulatory mechanism of NK and T-cell responses to antigenic challenge. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed on a FACScan

BD Pharmingen™ Purified Mouse Anti-Human NKB1 - Purified - Clone DX9 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: DX9

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-KIR3DL1 antibody (ABIN2689859)

DAndrea, Chang, Phillips, Lanier: "Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles." in: The Journal of experimental medicine, Vol. 184, Issue 2, pp. 789-94, (1996) (PubMed).

Sivori, Vitale, Bottino, Marcenaro, Sanseverino, Parolini, Moretta, Moretta: "CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies." in: European journal of immunology, Vol. 26, Issue 10, pp. 2487-92, (1996) (PubMed).

Wagtmann, Rajagopalan, Winter, Peruzzi, Long: "Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer." in: Immunity, Vol. 3, Issue 6, pp. 801-9, (1996) (PubMed).

Litwin, Gumperz, Parham, Phillips, Lanier: "NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules." in: The Journal of experimental medicine, Vol. 180, Issue 2, pp. 537-43, (1994) (PubMed).

Target Details for KIR3DL1

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Alternative Name: NKB1 (KIR3DL1 Products)

Synonyms: KIR3DL1 antibody, KIR3DL3 antibody, CD158E1 antibody, KIR antibody, KIR3DL1/S1 antibody, NKAT3 antibody, NKB1 antibody, NKB1B antibody, Kirl1 antibody, Kirl2 antibody, Krl1 antibody, killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 antibody, uncharacterized LOC100437736 antibody, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 antibody, KIR3DL1 antibody, LOC100437736 antibody, Kir3dl1 antibody

Background: Synonyms: KIR